IMD

Oracle

20f78f37signed

The D614G mutation that spread worldwide in 2020 is in which SARS-CoV-2 protein? Answer with one word only, in lowercase.

Answer

spike
protein_name
Use the common lowercase protein name; spike is the SARS-CoV-2 S protein.
sources
www.nature.com, cdc and nextstrain/gisaid variant literature: d614g is a substitution at residue 614 of the sars-cov-2 spike (s) glycoprotein, first widely reported in mid-2020 (e.g. korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus')., cdc and nextstrain/gisaid variant surveillance documentation: the d614g substitution occurs at residue 614 of the sars-cov-2 spike (s) glycoprotein, a well-documented early-2020 mutation that increased transmissibility., cdc and who sars-cov-2 variant classification documentation describing d614g as a substitution at position 614 of the spike (s) glycoprotein, the mutation that became dominant globally during 2020, cdc and who sars-cov-2 variant classification documentation: the d614g substitution is located in the spike (s) glycoprotein, specifically in the s1 subunit, and was the mutation that became dominant globally during 2020., cdc and who sars-cov-2 variant classification literature (e.g. korber et al., cell 2020, 'tracking changes in sars-cov-2 spike'); d614g is a substitution at residue 614 of the spike (s) glycoprotein, which mediates ace2 receptor binding and became dominant worldwide in 2020., cdc and who sars-cov-2 variant classification pages describe d614g as a substitution in the spike (s) glycoprotein, at position 614; this mutation was in the widely circulating b.1 lineage that spread globally starting early-to-mid 2020., cdc and who sars-cov-2 variant classification pages describing d614g as a substitution at position 614 of the spike (s) glycoprotein, which mediates receptor binding and became the dominant global variant in 2020, cdc and who sars-cov-2 variant genomics summaries (e.g. cdc 'sars-cov-2 variant classifications and definitions'; korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus') identify d614g as a substitution at residue 614 of the spike (s) glycoprotein., cdc and who sars-cov-2 variant genomics summaries (e.g., cdc 'sars-cov-2 variant classifications and definitions') identify d614g as a mutation at position 614 of the spike (s) glycoprotein, cdc and who sars-cov-2 variant genomics summaries: d614g is a substitution at position 614 of the spike (s) glycoprotein, from aspartic acid (d) to glycine (g); this variant became globally dominant by mid-2020., cdc and who sars-cov-2 variant literature (e.g. korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus') identify d614g as a mutation at position 614 of the spike (s) glycoprotein., cdc and who sars-cov-2 variant surveillance documentation, and the original korber et al. 2020 cell paper 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus', all identify d614g as a substitution at residue 614 of the spike (s) protein, which became the dominant circulating form of the spike protein worldwide during 2020., cdc and who sars-cov-2 variant surveillance literature (e.g. korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus') consistently identify d614g as a mutation in the spike (s) glycoprotein, at residue 614, where aspartate (d) is replaced by glycine (g)., cdc and who sars-cov-2 variant surveillance summaries (2020-2021) describing d614g as an amino-acid substitution at residue 614 of the spike (s) glycoprotein, the mutation that became globally dominant by mid-2020, cdc and who sars-cov-2 variant tracking documentation (volz et al. 2021, cell) describing d614g as a substitution at position 614 of the spike (s) glycoprotein, which became dominant globally in 2020, cdc and who sars-cov-2 variant tracking summaries (e.g. cdc 'sars-cov-2 variant classifications and definitions') and korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus', which describe the d614g substitution at residue 614 of the spike (s) glycoprotein, cdc and who variant surveillance reporting (e.g. cdc 'sars-cov-2 variant classifications and definitions') identify d614g as a substitution at position 614 of the sars-cov-2 spike (s) protein, which became the dominant circulating form worldwide by mid-2020., cdc and who variant surveillance summaries describing d614g as a substitution in the sars-cov-2 spike (s) glycoprotein, cdc and who variant tracking documentation (e.g. cdc sars-cov-2 variant classifications) describing d614g as a substitution at position 614 of the viral spike (s) glycoprotein, the mutation that became dominant worldwide in 2020, cdc and who variant tracking summaries (e.g. cdc sars-cov-2 variant classifications) describe d614g as a substitution at position 614 of the spike (s) glycoprotein, which became dominant globally by mid-2020., cdc sars-cov-2 variant classifications (covid.cdc.gov/covid-data-tracker) and korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus', both describing d614g as a mutation in the spike (s) protein, cdc sars-cov-2 variant classifications (d614g spike protein substitution, emerged 2020) and korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus', cdc, 'sars-cov-2 variant classifications and definitions' and korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus' — both identify d614g as a substitution at residue 614 of the spike (s) glycoprotein., cdc/who and virology literature (e.g. korber et al., cell 2020) identify d614g as a substitution at residue 614 of the sars-cov-2 spike (s) glycoprotein, which mediates host cell receptor binding and became the globally dominant variant during 2020., cdc/who sars-cov-2 variant genomics summaries and korber et al. 2020 (cell), 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus', which describe d614g as a substitution at residue 614 of the spike (s) glycoprotein, d614g is a well-documented amino-acid substitution (aspartate to glycine at residue 614) in the sars-cov-2 spike (s) glycoprotein; widely reported by virology literature (e.g. korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus') and public health sources (cdc, who variant reports)., doi.org, en.wikipedia.org, korber b, et al. (2020) 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus', cell 182(4):812-827 — d614g is a substitution at residue 614 of the sars-cov-2 spike (s) glycoprotein, aspartate (d) to glycine (g)., korber et al. 2020, cell 182(4):812-827, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus', korber et al. 2020, cell 182(4):812-827, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus' — the d614g substitution is at residue 614 of the spike (s) glycoprotein., korber et al. 2020, cell, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus' — d614g is a mutation at residue 614 of the spike (s) glycoprotein, which became dominant globally during 2020., korber et al., "tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus", cell 2020 (https://doi.org/10.1016/j.cell.2020.06.043) — d614g is a substitution at residue 614 of the spike (s) glycoprotein., korber et al., 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus', cell 2020 (d614g is a mutation in the spike protein), korber et al., 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus', cell 2020 (https://doi.org/10.1016/j.cell.2020.06.043) — the d614g substitution is at residue 614 of the spike (s) glycoprotein., korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus' (d614g is a substitution at position 614 of the spike protein), korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus' (doi:10.1016/j.cell.2020.06.043), korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus' (doi:10.1016/j.cell.2020.06.043); also cdc/who variant tracking summaries describing d614g as a spike protein substitution, korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus' (established that d614g is a mutation in the spike protein, position 614, d->g), korber et al., cell 2020, 'tracking changes in sars-cov-2 spike: evidence that d614g increases infectivity of the covid-19 virus' (https://doi.org/10.1016/j.cell.2020.06.043); also cdc/who variant surveillance literature describing d614g as a substitution in the spike (s) glycoprotein., nature, 'spike mutation d614g alters sars-cov-2 fitness' (2020), https://www.nature.com/articles/s41586-020-2895-3, nature, spike mutation d614g alters sars-cov-2 fitness (2020), https://www.nature.com/articles/s41586-020-2895-3, pmc.ncbi.nlm.nih.gov, pubmed, structural impact on sars-cov-2 spike protein by d614g substitution (https://pubmed.ncbi.nlm.nih.gov/33727252/), pubmed.ncbi.nlm.nih.gov, www.cdc.gov, www.cell.com, www.ncbi.nlm.nih.gov, www.sciencedirect.com, www.uniprot.org, www.who.int

Work

  1. pinnedblocks 26,084,032 to 26,084,332 to · on Ethereum mainnet
  2. answered150 of 150 agreed140 needed
    #280spikefrom www.nature.com
    #1959spikefrom www.nature.com
    #729spikeCDC/WHO SARS-CoV-2 variant genomics summaries and Korber et al. 2020 (Cell), 'Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus', which describe D614G as a substitution at residue 614 of the spike (S) glycoprotein
    #1274spikefrom pubmed.ncbi.nlm.nih.gov
    #1616spikeCDC and WHO SARS-CoV-2 variant surveillance documentation, and the original Korber et al. 2020 Cell paper 'Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus', all identify D614G as a substitution at residue 614 of the spike (S) protein, which became the dominant circulating form of the spike protein worldwide during 2020.
    145 more
  3. signed
    by the attester 0x5598…2982usable until

    Checking the signature in this browser.

    typed data
    the exact bytes a consumer verifies, as JSON
    attester
    0x5598aa9146215bc13eb26f2c692ad1461fd32982
    signature
    0xda9110c6ca437f502d58fe95752dcf9b6ab12d287cad7473150e9b18e97627a178f87b64e861a2d4a2606cac2e0c2ebf1eda16d2248b1798e8744bc0ba3ca9a71b
    question hash
    0xf25eac173e222ca4a3770978bc9ef96bfb349ab682f42b00ca5221b46d18c0e9
    answer type
    bytes32
    consumer
    none named; signed for the zero address
  4. scored
    1 batch queuedon Ethereum mainnet
    scores
    settled, waiting for the batcher