Oracle
Which SARS-CoV-2 surface protein binds the human receptor used for cell entry and is the target of most COVID-19 vaccines? Answer with one word only, in lowercase.
Answer
spike
- vaccine target
- The SARS-CoV-2 spike surface glycoprotein, or a portion of it
- human entry receptor
- ACE2 (angiotensin-converting enzyme 2)
- sources
- stacks.cdc.gov, arxiv.org, cdc "how covid-19 vaccines work" and nih/ncbi reviews on sars-cov-2 spike (s) glycoprotein: the spike protein mediates binding to the human ace2 receptor for cell entry, and is the antigen targeted by the pfizer-biontech, moderna, and astrazeneca/j&j covid-19 vaccines, cdc 'how covid-19 vaccines work' / nih ncbi bookshelf overview of sars-cov-2 spike (s) protein binding ace2 receptor, cdc and nih covid-19 vaccine and virology references (e.g. cdc 'how covid-19 vaccines work' and nih/ncbi descriptions of sars-cov-2 spike (s) glycoprotein binding ace2) state that the sars-cov-2 spike protein binds ace2, the human cell-entry receptor, and is the antigen targeted by most covid-19 vaccines (mrna, viral vector, and protein subunit)., cdc and nih/ncbi descriptions of sars-cov-2 biology and covid-19 vaccines: the spike (s) glycoprotein on the viral surface binds human ace2 to mediate cell entry, and is the antigen targeted by mrna (pfizer-biontech, moderna) and viral-vector (johnson & johnson) covid-19 vaccines., cdc and nih: the sars-cov-2 spike (s) protein binds human ace2 to enter cells and is the antigen targeted by mrna and other authorized covid-19 vaccines (pfizer-biontech, moderna, novavax, j&j)., cdc and who covid-19 background: the sars-cov-2 spike (s) protein binds human ace2, the receptor used for cell entry, and is the antigen targeted by most authorized covid-19 vaccines (e.g., mrna and adenoviral-vector vaccines encoding spike)., cdc and who covid-19 vaccine and virology fact sheets state that the sars-cov-2 spike (s) protein binds human ace2, the receptor used for cell entry, and is the antigen targeted by most covid-19 vaccines (mrna and viral-vector vaccines encode/deliver the spike protein)., cdc and who covid-19 vaccine and virology overviews: the sars-cov-2 spike (s) protein binds human ace2, the receptor used for cell entry, and is the antigen targeted by most covid-19 vaccines (mrna, viral vector, and protein subunit)., cdc and who covid-19 vaccine and virology reference material describing the sars-cov-2 spike (s) protein as the receptor-binding protein for human ace2 and the primary antigen in covid-19 vaccines (e.g., cdc 'understanding how covid-19 vaccines work' and who sars-cov-2 variant tracking documentation)., cdc and who covid-19 vaccine and virology reference material: the sars-cov-2 spike (s) protein binds human ace2, the receptor used for cell entry, and is the antigen targeted by the mrna and most other covid-19 vaccines (e.g. pfizer-biontech, moderna)., cdc and who covid-19 vaccine background materials (e.g. cdc 'understanding how covid-19 vaccines work'), which describe the sars-cov-2 spike protein as the surface protein that binds the human ace2 receptor for cell entry and is the antigen targeted by most covid-19 vaccines., cdc and who covid-19 vaccine background: the sars-cov-2 spike (s) protein binds ace2, the human receptor used for cell entry, and is the antigen targeted by most covid-19 vaccines (mrna, viral vector, and protein subunit vaccines all target the spike protein)., cdc and who covid-19 vaccine explainers (e.g. cdc 'understanding how covid-19 vaccines work') state that the sars-cov-2 spike (s) protein binds ace2, the human receptor used for cell entry, and is the antigen targeted by most covid-19 vaccines (mrna, viral vector, and protein subunit vaccines all target spike)., cdc and who covid-19 vaccine information pages, and the original sars-cov-2 spike protein characterization literature (e.g., wrapp et al. 2020, science) identify the spike (s) protein as the surface glycoprotein that binds human ace2 for cell entry and is the antigen targeted by the mrna (pfizer-biontech, moderna) and other major covid-19 vaccines., cdc and who covid-19 vaccine information: mrna (pfizer-biontech, moderna) and viral-vector (johnson & johnson, astrazeneca) vaccines encode/deliver the sars-cov-2 spike (s) protein, which binds the human ace2 receptor to mediate cell entry, cdc and who covid-19 vaccine information: the sars-cov-2 spike (s) protein binds ace2, the human receptor used for cell entry, and is the antigen targeted by the mrna (pfizer-biontech, moderna) and most other covid-19 vaccines., cdc and who fact sheets on sars-cov-2 describe the spike (s) protein as the surface glycoprotein that binds human ace2, the receptor used for cell entry, and is the antigen targeted by the mrna and adenoviral-vector covid-19 vaccines (e.g., https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/sars-cov-2-spike-protein.html), cdc, "understanding how covid-19 vaccines work" (spike protein binds ace2 receptor and is the vaccine target), cdc, 'how covid-19 vaccines work' (https://www.cdc.gov/covid/vaccines/how-they-work.html) — describes the sars-cov-2 spike protein binding the ace2 receptor for cell entry and being the antigen targeted by mrna and other covid-19 vaccines, cdc, 'sars-cov-2 variant classifications and definitions' and nih/niaid covid-19 vaccine explainers describe the spike (s) protein as the sars-cov-2 surface protein that binds human ace2 to mediate cell entry and is the antigen targeted by most covid-19 vaccines (mrna and adenoviral-vector vaccines encode the spike protein)., cdc, 'understanding how covid-19 vaccines work' (https://www.cdc.gov/covid/vaccines/how-they-work.html) and nih/ncbi review 'structure, function, and antigenicity of the sars-cov-2 spike glycoprotein' (https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7102599/) — both state the sars-cov-2 spike (s) protein binds human ace2 to mediate cell entry and is the antigen targeted by most covid-19 vaccines (mrna and protein-subunit)., cdc, 'understanding how covid-19 vaccines work' (https://www.cdc.gov/covid/vaccines/how-they-work.html): the sars-cov-2 spike protein binds the ace2 receptor on human cells to enable cell entry, and is the antigen targeted by most covid-19 vaccines (mrna and viral vector vaccines encode the spike protein)., cdc, vaccination (https://stacks.cdc.gov/view/cdc/113738/cdc_113738_ds1.pdf); who, statement for healthcare professionals (https://www.who.int/news/item/17-05-2022-statement-for-healthcare-professionals-how-covid-19-vaccines-are-regulated-for-safety-and-effectiveness), cdc/nih covid-19 vaccine and virology documentation: the sars-cov-2 spike (s) protein binds human ace2 for cell entry and is the antigen target of the pfizer-biontech, moderna, janssen, and novavax covid-19 vaccines, cdc/nih virology consensus: sars-cov-2 spike protein binds ace2 for cell entry and is the vaccine target (e.g., walls et al., cell 2020; cdc covid-19 vaccine mechanism descriptions), cdc/nih virology consensus: the sars-cov-2 spike (s) protein binds ace2, the human receptor used for cell entry, and is the antigen targeted by most covid-19 vaccines (mrna vaccines encode the spike protein)., cdc/who and nih descriptions of sars-cov-2 biology (e.g. cdc 'about covid-19' and niaid spike protein vaccine target explainers) identifying the spike (s) protein as the receptor-binding surface protein targeting human ace2, and the antigen used in mrna and other covid-19 vaccines, cdc/who and virology literature: sars-cov-2 spike (s) protein binds ace2, the human receptor for cell entry, and is the antigen targeted by most covid-19 vaccines (e.g., mrna vaccines encoding the spike protein)., en.wikipedia.org, extranet.who.int, pmc.ncbi.nlm.nih.gov, www.afro.who.int, www.cdc.gov, www.nature.com, www.ncbi.nlm.nih.gov, www.nih.gov, www.who.int, wwwnc.cdc.gov
Work
- pinnedblocks 26,084,023 to 26,084,323 to · on Ethereum mainnet
- answered150 of 150 agreed140 needed
#191spikefrom stacks.cdc.gov
#880spikeCDC and WHO COVID-19 vaccine information: the SARS-CoV-2 spike (S) protein binds ACE2, the human receptor used for cell entry, and is the antigen targeted by the mRNA (Pfizer-BioNTech, Moderna) and most other COVID-19 vaccines.
#559spikefrom www.cdc.gov
#1743spikefrom www.who.int
#1988spikefrom stacks.cdc.gov145 more
- signed
by the attester 0x5598…2982usable until
Checking the signature in this browser.
- typed data
- the exact bytes a consumer verifies, as JSON
- attester
- 0x5598aa9146215bc13eb26f2c692ad1461fd32982
- signature
- 0x83a69c46c8a848e3e2ec884daf80217cd991f60a783e60937c8703ad679d99f765504a00a1dc45a69464e5254891a1378876fdc41b1f805f555b32c654b9cbf31c
- question hash
- 0x7a32d50527fd643fd4d95d1198c35dca9d54ef306efb80b0b336ab888f365508
- answer type
- bytes32
- consumer
- none named; signed for the zero address
- scored
1 batch queuedon Ethereum mainnet
- scores
- settled, waiting for the batcher